Reproductive and developmental toxicity screening of polyhexamethylene guanidine phosphate by oral gavage in rats. 2019

Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology, Daejeon, Republic of Korea; College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.

Polyhexamethylene guanidine phosphate (PHMG-P) has effective antimicrobial activity against various microorganisms and has been widely used as a biocide in commercial products. However, its use as a humidifier disinfectant has provoked fatal idiopathic lung disease in South Korea, especially in pregnant or postpartum women and their young children. PHMG-P-related toxicological studies of reproduction and development in experimental animals have not been identified, and thus, we investigated the potential effects of early-stage oral exposure to PHMG-P by assessing its toxicological properties. PHMG-P was repeatedly administered by oral gavage at dose levels of 0, 13, 40 and 120 mg/kg to Sprague-Dawley rats during the pre-mating, mating, gestation and early lactation periods, and then general systemic and reproductive/developmental toxicities were investigated. At 120 mg/kg, PHMG-P-related toxicities including subdued behavior, thin appearance, decreased body weight, decreased food consumption and decreased F1 pup body weight were observed. Based on the results of this study, the no-observed-adverse-effect levels (NOAELs) of PHMG-P for both general systemic effects and development are considered to be 40 mg/kg/day.

UI MeSH Term Description Entries
D008297 Male Males
D008431 Maternal-Fetal Exchange Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission. Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D012098 Reproduction The total process by which organisms produce offspring. (Stedman, 25th ed) Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D005260 Female Females
D005298 Fertility The capacity to conceive or to induce conception. It may refer to either the male or female. Fecundity,Below Replacement Fertility,Differential Fertility,Fecundability,Fertility Determinants,Fertility Incentives,Fertility Preferences,Fertility, Below Replacement,Marital Fertility,Natural Fertility,Subfecundity,World Fertility Survey,Determinant, Fertility,Determinants, Fertility,Fertility Determinant,Fertility Incentive,Fertility Preference,Fertility Survey, World,Fertility Surveys, World,Fertility, Differential,Fertility, Marital,Fertility, Natural,Preference, Fertility,Preferences, Fertility,Survey, World Fertility,Surveys, World Fertility,World Fertility Surveys
D006146 Guanidines A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations

Related Publications

Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
October 2018, Zebrafish,
Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
May 2020, Toxics,
Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
January 2002, International journal of toxicology,
Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
November 1995, Fundamental and applied toxicology : official journal of the Society of Toxicology,
Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
January 1994, Fundamental and applied toxicology : official journal of the Society of Toxicology,
Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
January 2016, The Journal of toxicological sciences,
Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
January 2023, Chemosphere,
Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
May 2002, Drug and chemical toxicology,
Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
June 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology,
Jinsoo Lee, and Ji-Seong Jeong, and Sang Yun Kim, and Wan-Jung Im, and Young-Jun Shin, and Kyuhong Lee, and Seong-Jin Choi, and Yongju Heo, and Eun Ju Jeong, and Sang-Yoon Nam, and Wook-Joon Yu
January 1996, Toxicology and industrial health,
Copied contents to your clipboard!