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1. Eleven patients with type II diabetes mellitus were studied prior to, and after short- (10 days) and long-term (6 months) glibenclamide treatment. 2. A marked decrease in glucose level was observed after short- and long-term therapy using the oral glucose tolerance test (OGTT) and diet test (DT). 3. After short-term therapy, insulin level increased by 52.5% with the OGTT and by 37.6% with the DT; after long-term therapy, the increases were 78.6% and 69.5%, respectively. 4. Insulin binding to erythrocytes was unchanged by short- or long-term glibenclamide therapy. 5. These data suggest that the hypoglycemic effect of glibenclamide results from an increase in insulin secretion and that extrapancreatic actions at the receptor or post-receptor level are not necessarily involved.
L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
March 1985,
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L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
April 1999,
JPMA. The Journal of the Pakistan Medical Association,
L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
October 1981,
Acta medica Okayama,
L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
January 1984,
Clinical and investigative medicine. Medecine clinique et experimentale,
L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
December 1984,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
November 1982,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
December 1983,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
June 1991,
Nederlands tijdschrift voor geneeskunde,
L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
October 1982,
Endocrinologia japonica,
L M Araujo, and
M J Ursich, and
A A Pupo, and
R T Fukui
March 2004,
Endocrinology and metabolism clinics of North America,
