Cyclosporin A in children with persistent renal transplant rejection and progressively deteriorating graft function. 1987

D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
Department of Pediatrics, Hospital for Sick Children, Ontario, Canada.

The effect on renal function and growth of switching from azathioprine to cyclosporin A (CyA) was prospectively evaluated in ten children with persistent renal transplant rejection. Progression of renal insufficiency during CyA therapy was compared with that before using CyA. Prednisone administration decreased after CyA was introduced and although growth retardation persisted, height velocity improved significantly. Renal function stabilized in seven patients treated with CyA for a variable time period, and four of these children remain off dialysis 0.44-1.42 years later. Renal biopsies were obtained in seven children when they were converted from azathioprine to CyA. The response to CyA could not be predicted from renal morphology or clinical features.

UI MeSH Term Description Entries
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003524 Cyclosporins A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection. Cyclosporines
D005260 Female Females
D006084 Graft Rejection An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. Transplant Rejection,Rejection, Transplant,Transplantation Rejection,Graft Rejections,Rejection, Graft,Rejection, Transplantation,Rejections, Graft,Rejections, Transplant,Rejections, Transplantation,Transplant Rejections,Transplantation Rejections
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D016030 Kidney Transplantation The transference of a kidney from one human or animal to another. Grafting, Kidney,Renal Transplantation,Transplantation, Kidney,Transplantation, Renal,Kidney Grafting,Kidney Transplantations,Renal Transplantations,Transplantations, Kidney,Transplantations, Renal

Related Publications

D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
August 1989, Transplantation proceedings,
D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
March 1993, American journal of kidney diseases : the official journal of the National Kidney Foundation,
D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
January 1985, American journal of nephrology,
D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
December 1984, Transplantation proceedings,
D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
August 1998, Transplantation proceedings,
D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
August 1980, Schweizerische medizinische Wochenschrift,
D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
August 1991, Annals of allergy,
D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
April 1985, The Alabama journal of medical sciences,
D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
July 1985, Lancet (London, England),
D F Geary, and P Thorner, and R Baumal, and M Major, and G Arbus
May 1984, Transplantation,
Copied contents to your clipboard!