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Three-Component Cascade Bis-heteroannulation of Aryl or Vinyl Methylketoxime Acetates toward Thieno[3,2-c]isoquinolines. 2019

Zhenhua Xu, and Guo-Jun Deng, and Feng Zhang, and Hongbiao Chen, and Huawen Huang
Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry , Xiangtan University , Xiangtan 411105 , China.

A three-component cascade bis-heteroannulation reaction is described that provides access to a variety of benzo[4,5]thieno[3,2-c]isoquinoline and thieno[3,2-c]isoquinoline compounds from easily available methylketoximes, o-halobenzaldehydes, and elemental sulfur. Mechanistic studies reveal a two-step process involving a sequential copper and sulfur catalysis relay.

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