-transparent.png){kind=logo}
A number of 2-benzylaminophenols, prepared from the corresponding 2-aminophenols by reductive alkylation, have been identified as highly potent inhibitors of 5-lipoxygenase with IC50 values in the nanomolar range. Most compounds were also shown to inhibit the release of the peptidoleukotrienes when administered intraperitoneally in a rat model of peritoneal anaphylaxis. Two compounds evaluated for their effects on anaphylactic contractions in isolated human lung were shown to attenuate the leukotriene-induced component of the response.
Related Publications
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
September 1985,
The Journal of biological chemistry,
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
November 1985,
FEBS letters,
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
January 2017,
Biochemical pharmacology,
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
November 1989,
Agents and actions,
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
September 1986,
Chemical & pharmaceutical bulletin,
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
August 1988,
Biochemical pharmacology,
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
September 1984,
Biochemical pharmacology,
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
May 1989,
Biochemical pharmacology,
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
July 2011,
Pharmaceutical biology,
D R Buckle, and
J Bumstead, and
G D Clarke, and
K A Foster, and
H Parr, and
J F Taylor, and
V E Thody, and
R A Webster
November 2006,
Medicinal chemistry (Shariqah (United Arab Emirates)),
