BIOMAT Database Logo BIOMAT Database Logo

Problems in monitoring mutagenicity of human urine. 1988

H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
Faculty of Pharmaceutical Sciences, Okayama University, Japan.

Blue-cotton (-rayon) adsorbable fractions of human urines were examined for mutagenicity in Salmonella typhimurium TA98 with metabolic activation. Ingestion of cooked beef caused significant increases in urinary mutagenicity that were comparable to that caused by cigarette smoking. When a sample obtained after ingestion of cooked beef was passed through a carboxymethyl cellulose column, the mutagenicity of the eluate was found to be almost one order of magnitude greater than that of the original sample, suggesting the presence of antimutagenic factors in the sample. The oleic acid content of the sample was not great enough to account for this phenomenon. Other urine samples subjected to column fractionation were found to contain the putative antimutagenic factors. This finding further confounds the monitoring of urinary mutagenicity.

UI MeSH Term Description Entries
D008460 Meat The edible portions of any animal used for food including cattle, swine, goats/sheep, poultry, fish, shellfish, and game. Meats
D009152 Mutagenicity Tests Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests. Genetic Toxicity Tests,Genotoxicity Tests,Mutagen Screening,Tests, Genetic Toxicity,Toxicity Tests, Genetic,Genetic Toxicity Test,Genotoxicity Test,Mutagen Screenings,Mutagenicity Test,Screening, Mutagen,Screenings, Mutagen,Test, Genotoxicity,Tests, Genotoxicity,Toxicity Test, Genetic
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D004784 Environmental Monitoring The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment. Monitoring, Environmental,Environmental Surveillance,Surveillance, Environmental
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012907 Smoking Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand. Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits
D014556 Urine Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.

Related Publications

H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
Mutagenicity studies with nitrofurans. III. Mutagenicity testing of nitrofurylacrylic acid in human blood and urine.
January 1980, Mutation research,
H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
Mutagenicity of metronidazole: presence of several active metabolites in human urine.
February 1976, Journal of the National Cancer Institute,
H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
The use of a urine mutagenicity assay in the monitoring of environmental exposure to genotoxins.
June 1997, Mutation research,
H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
Monitoring mutagenicity in urine and peripheral blood lymphocytes of pharmacists occupationally exposed to anticancer drugs.
January 1990, The New Zealand medical journal,
H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
Mutagenicity of human urine after the consumption of fried salted salmon.
February 1987, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
Biological monitoring of human exposure to coal tar. Urinary mutagenicity assays and analytical determination of polycyclic aromatic hydrocarbon metabolites in urine.
January 1990, IARC scientific publications,
H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
Statistical problems in mutagenicity tests.
September 1977, Archives of toxicology,
H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
Mutagenicity of urine from greenhouse workers.
January 1988, Journal of toxicology and environmental health,
H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
Urine mutagenicity of petroleum plant workers.
October 1989, Mutation research,
H Hayatsu, and T Hayatsu, and Q L Zheng, and Y Ohara, and S Arimoto
The mutagenicity of cigarette smokers' urine.
January 1985, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
Copied contents to your clipboard!