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In late 1986, several vials of Humulin N (NPH human insulin, recombinant DNA origin) came to our attention because of a clumped, white coating on the inside of the vials. To determine the frequency of this phenomenon, we surveyed 100 consecutive patients who used Humulin N. Ten patients had encountered 21 vials of flocculated insulin in the previous 12 mo, reflecting an incidence of 1 per 72 vials. Insulin drawn from affected vials was markedly reduced in potency: 20.9 +/- 3.4 U/ml vs. the labeled potency of 100 U/ml. Several patients reporting flocculated insulin, including one hospitalized with ketoacidosis, experienced unusual and unexplained elevation in blood glucose concentration for several days before flocculation was observed. Patients who use NPH human insulin should be aware of this phenomenon and carefully inspect their vials for evidence of insulin precipitation before each injection.
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
January 1994,
Revista clinica espanola,
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
January 1982,
Diabetes care,
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
May 1983,
MMW, Munchener medizinische Wochenschrift,
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
January 1987,
Diabetic medicine : a journal of the British Diabetic Association,
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
February 1962,
Gazette medicale de France,
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
November 1950,
The Journal of the Maine Medical Association,
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
July 1951,
Canadian Medical Association journal,
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
April 1951,
The Journal of the Oklahoma State Medical Association,
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
August 1951,
Journal - Michigan State Medical Society,
E A Benson, and
J W Benson, and
P N Fredlund, and
R S Mecklenburg, and
R Metz
April 1989,
Deutsche medizinische Wochenschrift (1946),
