Biomaterial Database

Negative-Pressure Wound Therapy to Reduce Wound Complications after Abdominoperineal Resection. 2020

Rebecca Gologorsky, and Shruti Arora, and Anahita Dua

Department of Surgery, University of California San Francisco-East Bay, Oakland.

Abdominoperineal resection is associated with a high rate of wound complications. A high degree of wound tension, a common contributor to wound breakdown and complications, may be mitigated by incisional negative-pressure wound therapy (NPWT). Although NPWT has been shown to reduce complications associated with open and complex wounds, there is a paucity of data regarding its prophylactic use for incisional wounds. To determine the effect of NPWT use on surgical wound complications of abdominoperineal resection for malignancy. We performed a systematic review by querying the PubMed database for studies from 1990 to 2019 and included English-language studies that used incisional NPWT for closed wounds from abdominoperineal resection in malignancy cases. Five studies with a total of 76 patients were included. Their findings showed reduced rates of surgical site complications with the use of incisional NPWT. Another 2 studies describing the use of prophylactic NPWT to expedite secondary closure of the surgical wound followed by incisional wound therapy were separately categorized and included 8 patients, none of whom experienced wound wound complications. Additional, prospective research is needed to confirm the benefit of prophylactic incisional NPWT.

UI	MeSH Term	Description	Entries
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D012004	Rectal Neoplasms	Tumors or cancer of the RECTUM.	Cancer of Rectum,Rectal Cancer,Rectal Tumors,Cancer of the Rectum,Neoplasms, Rectal,Rectum Cancer,Rectum Neoplasms,Cancer, Rectal,Cancer, Rectum,Neoplasm, Rectal,Neoplasm, Rectum,Rectal Cancers,Rectal Neoplasm,Rectal Tumor,Rectum Cancers,Rectum Neoplasm,Tumor, Rectal
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000078542	Proctectomy	Surgical resection of the RECTUM.	Abdomino-Perineal Rectum Excision,Abdomino-Perineal Resection,Abdomino-perineal Excision,Abdominoperineal Excision,Abdominoperineal Rectum Excision,Abdominoperineal Resection,Rectum Excision,Rectum Resection,Abdomino Perineal Rectum Excision,Abdomino Perineal Resection,Abdomino perineal Excision,Abdomino-Perineal Rectum Excisions,Abdomino-Perineal Resections,Abdomino-perineal Excisions,Abdominoperineal Excisions,Abdominoperineal Rectum Excisions,Abdominoperineal Resections,Excision, Abdomino-Perineal Rectum,Excision, Abdomino-perineal,Excision, Abdominoperineal,Excision, Abdominoperineal Rectum,Excision, Rectum,Excisions, Abdomino-Perineal Rectum,Proctectomies,Rectum Excision, Abdomino-Perineal,Rectum Excision, Abdominoperineal,Rectum Excisions,Rectum Resections,Resection, Abdomino-Perineal,Resection, Abdominoperineal,Resection, Rectum,Resections, Abdominoperineal
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D012307	Risk Factors	An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.	Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D012720	Severity of Illness Index	Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.	Illness Index Severities,Illness Index Severity
D012737	Sex Factors	Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.	Factor, Sex,Factors, Sex,Sex Factor
D013530	Surgical Wound Infection	Infection occurring at the site of a surgical incision.	Postoperative Wound Infection,Infection, Postoperative Wound,Infection, Surgical Wound,Surgical Site Infection,Wound Infection, Postoperative,Wound Infection, Surgical,Infection, Surgical Site,Infections, Postoperative Wound,Infections, Surgical Site,Infections, Surgical Wound,Postoperative Wound Infections,Surgical Site Infections,Surgical Wound Infections,Wound Infections, Postoperative,Wound Infections, Surgical
D054843	Negative-Pressure Wound Therapy	The application of a vacuum across the surface of a wound through a foam dressing cut to fit the wound. This removes wound exudates, reduces build-up of inflammatory mediators, and increases the flow of nutrients to the wound thus promoting healing.	Negative-Pressure Dressings,Topical Negative-Pressure Therapy,Vacuum-Assisted Closure,Closure, Vacuum-Assisted,Closures, Vacuum-Assisted,Dressing, Negative-Pressure,Dressings, Negative-Pressure,Negative Pressure Dressings,Negative Pressure Wound Therapy,Negative-Pressure Dressing,Negative-Pressure Therapies, Topical,Negative-Pressure Therapy, Topical,Negative-Pressure Wound Therapies,Therapies, Negative-Pressure Wound,Therapies, Topical Negative-Pressure,Therapy, Negative-Pressure Wound,Therapy, Topical Negative-Pressure,Topical Negative Pressure Therapy,Topical Negative-Pressure Therapies,Vacuum Assisted Closure,Vacuum-Assisted Closures,Wound Therapies, Negative-Pressure,Wound Therapy, Negative-Pressure