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The effect of prostaglandin E1 on thrombus formation and haemostasis was investigated in a standardized experimental model in 20 rabbits. Arterial thrombus formation was reduced significantly by 70% and venous thrombosis by 68% in comparison with the controls. Collagen- and ADP-induced platelet aggregation was also inhibited significantly. Additionally, the time lag until onset of collagen-induced aggregation was significantly prolonged. Platelet count however, and plasma coagulation time showed no change. The data demonstrate a clear inhibition of arterial and venous thrombus formation, suggesting a powerful antithrombotic activity of prostaglandin E1. The effect may be explained by an influence on platelet function. The data further indicate that a full antithrombotic effect is achieved during prostaglandin E1 infusion.
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
March 1973,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
January 1972,
Haemostasis,
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
January 1976,
Acta biologica et medica Germanica,
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
October 1972,
Annales de medecine interne,
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
May 1994,
Masui. The Japanese journal of anesthesiology,
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
July 1987,
Annals of plastic surgery,
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
February 1997,
General pharmacology,
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
August 1992,
Transplantation proceedings,
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
January 1991,
VASA. Supplementum,
R Zimmermann, and
J Stadler, and
J Harenberg, and
W Kübler
January 1997,
International journal of colorectal disease,
