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Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats. 1988

I Ikai, and Y Shimahara, and S Wakashiro, and N Ozaki, and Y Tokunaga, and A Tanaka, and T Morimoto, and K Ozawa
Second Department of Surgery, Kyoto University Facility of Medicine, Japan.

The influence of hemorrhagic shock on hepatic energy metabolism was investigated in carbon tetrachloride (CCl4)-induced cirrhotic rat. In normal and CCl4-treated rats, the hepatic mitochondrial redox state and phosphorylative activity decreased significantly (P less than 0.001) following hemorrhagic shock, with mean arterial blood pressure at 30 mmHg. In normal rats, they were immediately restored upon reinfusion of shed blood after 2 hr of hemorrhagic shock, followed by marked enhancement 120 min later. By contrast, in cirrhotic rats redox state and phosphorylative activity in hepatic mitochondria did not recover immediately, and there was neither elevation of redox state nor enhancement of phosphorylative activity in hepatic mitochondria. The survival rate at 24 hr was 10% in contrast to 90% in normal rats. These results suggest that the absence of early recovery followed by enhancement of mitochondrial function in the cirrhotic liver is fundamentally related to the mechanism of hepatic failure following hemorrhagic shock.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D007773 Lactates Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008106 Liver Cirrhosis, Experimental Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS. Hepatic Cirrhosis, Experimental,Cirrhoses, Experimental Liver,Cirrhosis, Experimental Liver,Experimental Liver Cirrhoses,Experimental Liver Cirrhosis,Liver Cirrhoses, Experimental,Experimental Hepatic Cirrhosis
D008297 Male Males
D008930 Mitochondria, Liver Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4) Liver Mitochondria,Liver Mitochondrion,Mitochondrion, Liver
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D010766 Phosphorylation The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety. Phosphorylations
D011773 Pyruvates Derivatives of PYRUVIC ACID, including its salts and esters.
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat

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