Alcohol binge-drinking damage on the vestibulo-oculomotor reflex. 2021

Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100, Rome, Italy.

OBJECTIVE Binge drinking is associated with several adverse effects in multiple organs. This study aimed at evaluating the effects of a binge-like-drinking on the vestibulo-oculomotor reflex (VOR) using the video Head Impulse Test (vHIT) and the functional Head Impulse Test (fHIT). METHODS Eleven healthy men (age range 32-35 years) with moderate drinking habits and no history of vestibular dysfunction were enrolled. A preliminary assessment of breath alcohol concentration (BrAC) to check for zero alcohol value and a pre-intake evaluation of VOR using the vHIT and the fHIT were carried on. Then, the subjects were asked to take drinks with different alcohol content (8-40% ethanol by volume) according to their choice, consuming at least 5 standard drinks. Volunteers stopped drinking after 3 h. After a further 30 min, post-intake BrAC measurements and VOR analysis were repeated. RESULTS After alcohol intake, vHIT recorded an overall significant reduction of VOR gain (0.82 ± 0.07 on both sides) although the outcomes were below the normal range only in the four subjects with the highest blood alcohol levels. The post-intake fHIT outcomes were substandard in 9 participants, with a significant deterioration in performance (% of exact answers = 84.54 ± 11.05% on the left, 83.18 ± 14.53 on the right). CONCLUSIONS Binge drinking severely affects VOR; fHIT seems more sensitive than vHIT in the assessment of VOR function for complex vestibular lesions, such as those determined by ethanol, suggesting that fHIT could support vHIT in vestibular dysfunction assessment.

UI MeSH Term Description Entries
D008297 Male Males
D012027 Reflex, Vestibulo-Ocular A reflex wherein impulses are conveyed from the cupulas of the SEMICIRCULAR CANALS and from the OTOLITHIC MEMBRANE of the SACCULE AND UTRICLE via the VESTIBULAR NUCLEI of the BRAIN STEM and the median longitudinal fasciculus to the OCULOMOTOR NERVE nuclei. It functions to maintain a stable retinal image during head rotation by generating appropriate compensatory EYE MOVEMENTS. Vestibulo-Ocular Reflex,Reflex, Vestibuloocular,Reflexes, Vestibo-Ocular,Reflexes, Vestibuloocular,Reflex, Vestibulo Ocular,Reflexes, Vestibo Ocular,Vestibo-Ocular Reflexes,Vestibulo Ocular Reflex,Vestibuloocular Reflex,Vestibuloocular Reflexes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000428 Alcohol Drinking Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking. Alcohol Consumption,Alcohol Intake,Drinking, Alcohol,Alcohol Drinking Habits,Alcohol Drinking Habit,Alcohol Intakes,Consumption, Alcohol,Drinking Habit, Alcohol,Habit, Alcohol Drinking,Habits, Alcohol Drinking,Intake, Alcohol
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D014722 Vestibule, Labyrinth An oval, bony chamber of the inner ear, part of the bony labyrinth. It is continuous with bony COCHLEA anteriorly, and SEMICIRCULAR CANALS posteriorly. The vestibule contains two communicating sacs (utricle and saccule) of the balancing apparatus. The oval window on its lateral wall is occupied by the base of the STAPES of the MIDDLE EAR. Vestibular Apparatus,Ear Vestibule,Vestibular Labyrinth,Vestibule of Ear,Vestibulum Auris,Apparatus, Vestibular,Ear Vestibules,Labyrinth Vestibule,Labyrinth Vestibules,Labyrinth, Vestibular,Labyrinths, Vestibular,Vestibular Labyrinths,Vestibule, Ear,Vestibules, Ear,Vestibules, Labyrinth
D014741 Video Recording The storing or preserving of video signals to be played back later via a transmitter or receiver. Audiovisual Recording,Videorecording,Audiovisual Recordings,Recording, Audiovisual,Recording, Video,Recordings, Audiovisual,Recordings, Video,Video Recordings,Videorecordings
D015837 Vestibular Diseases Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls. Disease, Vestibular,Diseases, Vestibular,Vestibular Disease
D063425 Binge Drinking Drinking an excessive amount of ALCOHOLIC BEVERAGES in a short period of time. Binge Alcohol Consumption,Alcohol Consumption, Binge,Drinking, Binge

Related Publications

Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
January 1967, Journal de physiologie,
Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
February 1975, Nihon Jibiinkoka Gakkai kaiho,
Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
January 1981, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
January 2019, Vestnik otorinolaringologii,
Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
May 1982, Experimental neurology,
Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
December 2016, Health economics review,
Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
January 1990, Journal of vestibular research : equilibrium & orientation,
Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
January 1973, Experimental brain research,
Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
May 2019, Revue medicale de Liege,
Salvatore Martellucci, and Massimo Ralli, and Giuseppe Attanasio, and Francesca Yoshie Russo, and Vincenzo Marcelli, and Antonio Greco, and Andrea Gallo, and Marco Fiore, and Carla Petrella, and Giampiero Ferraguti, and Mauro Ceccanti, and Marco de Vincentiis
January 2011, Annals of the New York Academy of Sciences,
Copied contents to your clipboard!