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Fourteen schizophrenic patients and five patients with affective disorders were given naloxone (0.4 to 10 milligrams) or placebo intravenously in a double-blind fashion. Physicians' ratings of hallucinations, mannerisms and posturing, conceptual disorganization, psychosis, and mood did not change significantly. A single item, unusual thought content, improved significantly on the naloxone day compared to the placebo day. There was no improvement in mood in affectively ill patients rated either by themselves or by physicians. Naloxone did not markedly improve any patient studied, which suggests that the acute blockade of opiate receptors is not associated with global improvement in psychotic symptomatology.
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
August 1984,
Psychiatry research,
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
April 1991,
Biological psychiatry,
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
January 1978,
Psychiatria clinica,
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
January 1990,
Pharmacology & toxicology,
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
May 1985,
Biological psychiatry,
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
January 1984,
European archives of psychiatry and neurological sciences,
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
February 1979,
Biological psychiatry,
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
June 1995,
The British journal of psychiatry : the journal of mental science,
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
January 1975,
Research publications - Association for Research in Nervous and Mental Disease,
G C Davis, and
W E Bunney, and
E G DeFraites, and
J E Kleinman, and
D P van Kammen, and
R M Post, and
R J Wyatt
February 1978,
Hospital & community psychiatry,
