-transparent.png){kind=logo}
The immunoregulatory effect of 1 alpha-OHD3, a precursor form of active vitamin D3 1,25 (OH)2D3, was examined in hemodialysis patients. Peripheral blood mononuclear cells (PBM) from hemodialysis patients produced significantly less interleukin-2 (IL-2) than those from normal controls. Four weeks of oral administration of 0.5 micrograms/day of 1 alpha-OHD3 enhanced the IL-2 production of PBM from the patients. This fact suggests that 1 alpha-OHD3 therapy may be useful for the restoration of IL-2 production in hemodialysis patients, and that the vitamin D3 deficiency may be responsible for the impairment of cellular immunity associated with IL-2 production disorder in hemodialysis patients.
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
February 1991,
Clinical nephrology,
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
January 1989,
Nephron,
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
November 1977,
JAMA,
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
December 1982,
The Tohoku journal of experimental medicine,
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
November 1986,
The Journal of clinical endocrinology and metabolism,
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
January 1992,
American journal of nephrology,
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
January 1980,
Minerva nefrologica,
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
January 1978,
Prikladnaia biokhimiia i mikrobiologiia,
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
August 1990,
Journal of nutritional science and vitaminology,
T Tabata, and
T Shoji, and
K Kikunami, and
Y Matsushita, and
T Inoue, and
S Tanaka, and
M Hino, and
T Miki, and
Y Nishizawa, and
H Morii
January 1993,
Journal of orthopaedic research : official publication of the Orthopaedic Research Society,
