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Although the clearance of many oxidized drugs falls with age, a corresponding fall in the maximal activities of drug metabolizing enzymes has not been noted. The possibility of a fall in enzyme affinity for substrate with age, which could account for the observed changes, has not previously been investigated in human liver. We have studied the kinetics of the microsomal mono-oxygenase 7-ethoxycoumarin-O-de-ethylase in 17 human liver biopsy specimens. No correlation was observed between age and microsomal protein recovery, maximal enzyme activity or apparent enzyme affinity. Since microsomal mono-oxygenase activities and affinities appear not to change in human liver, other factors such as a fall in liver volume or blood flow must be responsible for the decline in clearance of many oxidized drugs which occurs with ageing.
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
August 1982,
Xenobiotica; the fate of foreign compounds in biological systems,
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
August 1983,
Mutation research,
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
January 1983,
Xenobiotica; the fate of foreign compounds in biological systems,
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
January 1993,
Vestnik Rossiiskoi akademii meditsinskikh nauk,
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
January 1975,
Chemico-biological interactions,
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
June 1976,
Chemico-biological interactions,
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
March 1972,
The Journal of pharmacology and experimental therapeutics,
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
April 2002,
Biochemical and biophysical research communications,
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
April 1984,
Xenobiotica; the fate of foreign compounds in biological systems,
H A Wynne, and
E Mutch, and
O F James, and
P Wright, and
M D Rawlins, and
K W Woodhouse
July 1983,
Die Pharmazie,
