-transparent.png){kind=logo}
1. 1,3-Cyclohexadiene exhibits type I binding spectra with microsomal cytochrome P-450 of either untreated, or phenobarbital- or 3-methylcholanthrene-treated mice. In all cases, two values of Ks can be measured, indicating a different affinity of 1,3-cyclohexadiene towards the cytochrome P-450 species. 2. Mouse-liver microsomal mono-oxygenase metabolizes 1,3-cyclohexadiene to the corresponding mono-epoxide, which is rapidly hydrolysed to trans-3-cyclohexene-1,2-diol and trans-2-cyclohexene-1,4-diol. This hydrolysis was proved to be essentially nonenzymic. 3. A simple gas-chromatographic method was used to quantify the diols and to determine the kinetic constants (Km and Vmax) of 1,3-cyclohexadiene mono-epoxidase. 4. Epoxide formation, as determined by diol production from 1,3-cyclohexadiene metabolism, was NADPH- and O2-dependent and was inhibited by CO and SKF-525A.
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
October 1983,
Xenobiotica; the fate of foreign compounds in biological systems,
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
October 1983,
Xenobiotica; the fate of foreign compounds in biological systems,
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
October 1985,
Xenobiotica; the fate of foreign compounds in biological systems,
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
January 1986,
Voprosy meditsinskoi khimii,
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
August 1983,
Mutation research,
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
January 1982,
Xenobiotica; the fate of foreign compounds in biological systems,
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
November 1988,
Age and ageing,
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
February 1982,
Xenobiotica; the fate of foreign compounds in biological systems,
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
January 1978,
Journal of agricultural and food chemistry,
P G Gervasi, and
L Citti, and
G Turchi, and
G Bellucci, and
G Berti, and
E Mastrorilli, and
M P Tortello
March 1972,
The Journal of pharmacology and experimental therapeutics,
