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Effect of short course chemotherapy on salivary paracetamol elimination. 1988
K Madhusudanarao, and
J S Bapna, and
C Adithan, and
K Ray, and
N Venkatadri, and
G L Kamatchi, and
M L Seetharaman, and
P Bahadur
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India.
1. Salivary elimination of paracetamol was studied in six male pulmonary tuberculosis patients on short course chemotherapy. 2. Peak paracetamol concentration showed a steady decrease at the end of first week and continued until the end of the study. 3. The elimination half-life of paracetamol decreased 5 weeks after the therapy with a corresponding increase in the clearance rate. 4. Adjustment of dosage of drugs that are metabolized by the microsomal enzymes may be required in patients on anti-tubercular drug regimen in which rifampicin is included.
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C Adithan, and
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