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The effect of trichloroethylene (Trielene) anaesthesia was studied in 10 young male patients undergoing short surgical procedures. Equal number of males operated upon for the same indication under epidural anaesthesia, served as a control group. Paracetamol concentrations in saliva were measured at hourly intervals on the day before and after surgery. Paracetamol half life (t1/2) significantly decreased (from 2.5 to 0.84 h) and clearance rate (CL) significantly increased (from 8.0 to 14.0 ml/min/kg) as compared to preoperative values. The control also showed significant but smaller alterations in these parameters. Our result suggests that trielene exposure may accelerate the hepatic metabolism of paracetamol.
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
January 1986,
European journal of clinical pharmacology,
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
June 1988,
Clinical and experimental pharmacology & physiology,
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
August 1985,
British journal of clinical pharmacology,
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
August 1988,
Clinical and experimental pharmacology & physiology,
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
March 1987,
British journal of clinical pharmacology,
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
September 1987,
Clinical and experimental pharmacology & physiology,
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
October 1978,
Food and cosmetics toxicology,
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
January 1973,
British journal of anaesthesia,
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
July 1972,
British journal of anaesthesia,
K Ray, and
C C Sahana, and
S B Chaudhuri, and
G C De, and
K Chatterjee
June 1972,
British journal of anaesthesia,
