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Because of its chiralic alpha-phosphorus atom adenosine 5'-O-(1-thiotriphosphate) (ATPalphaS) exists in two diastereomeric forms, arbitrarily named (A) and (B). For phenylalanyl-tRNA synthetase ATPalphaS (A) is a substrate whereas ATPalphaS (B) is neither a substrate nor an inhibitor. During the ATPalphaS (A)/PPi exchange reaction with phenylalanyl-tRNA synthetase the configuration at the alpha-phosphorus is retained. The mechanistic implications of these findings are discussed. Preliminary investigations with several other aminoacyl-tRNA synthetases show that the stereochemical requirement with respect to the alpha-phosphorus of ATP is not identical for all aminoacyl-tRNA synthetases.
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
October 1970,
Biochimica et biophysica acta,
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
December 1975,
Canadian journal of biochemistry,
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
December 1977,
FEBS letters,
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
June 1976,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
December 1974,
European journal of biochemistry,
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
November 1974,
European journal of biochemistry,
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
August 1982,
European journal of biochemistry,
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
May 1975,
European journal of biochemistry,
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
July 1977,
Biochemistry,
F von der Haar, and
F Cramer, and
F Eckstein, and
K W Stahl
January 1989,
FEBS letters,
