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Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase. 2021

Verena Weissert, and Bettina Rieger, and Silke Morris, and Tasnim Arroum, and Olympia Ekaterini Psathaki, and Thomas Zobel, and Guy Perkins, and Karin B Busch
Center of Cellular Nanoanalytics, Integrated Bioimaging Facility, University of Osnabrück, 49076 Osnabrück, Lower Saxony, Germany.

UI MeSH Term Description Entries
D008928 Mitochondria Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed) Mitochondrial Contraction,Mitochondrion,Contraction, Mitochondrial,Contractions, Mitochondrial,Mitochondrial Contractions
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D006367 HeLa Cells The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. Cell, HeLa,Cells, HeLa,HeLa Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000097795 ATPase Inhibitory Protein CA(2+) MG(2+)-ATPASE inhibitor found in membranes of mammalian ERYTHROCYTES. Epsilon Subunit, F1-ATPase,F(0)F(1)-Inhibitor Protein,F1-ATPase Epsilon Subunit,Inhibitor Factor 1, ATPase,Na-K ATPase Inhibitor
D019943 Amino Acid Substitution The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties. Amino Acid Substitutions,Substitution, Amino Acid,Substitutions, Amino Acid
D020125 Mutation, Missense A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed) Missense Mutation,Missense Mutations,Mutations, Missense
D025261 Mitochondrial Proton-Translocating ATPases Proton-translocating ATPases responsible for ADENOSINE TRIPHOSPHATE synthesis in the MITOCHONDRIA. They derive energy from the respiratory chain-driven reactions that develop high concentrations of protons within the intermembranous space of the mitochondria. Electron Transport Complex V,Mitochondrial ATP Synthase,Respiratory Complex V,Mitochondrial ATP Synthases,Mitochondrial F(1)F(0) ATPase,ATP Synthase, Mitochondrial,ATP Synthases, Mitochondrial,ATPases, Mitochondrial Proton-Translocating,Mitochondrial Proton Translocating ATPases,Proton-Translocating ATPases, Mitochondrial

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