Biomaterial Database

Chronic myelomonocytic leukemia terminating as malignant histiocytosis. 1987

D C Doll, and T M Grogan, and B R Greenberg

Veterans Administration Medical Center, Phoenix, Arizona 85012.

A patient with a 3.5 year history of chronic myelomonocytic leukemia who transformed to malignant histiocytosis is reported. The terminal event was characterized by fever, hepatosplenomegaly, thrombocytopenia, and a leukemic blood picture. The pathogenesis of this terminal transformation and proposed future studies are discussed.

UI	MeSH Term	Description	Entries
D008198	Lymph Nodes	They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.	Lymph Node,Node, Lymph,Nodes, Lymph
D008297	Male		Males
D001853	Bone Marrow	The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.	Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D002471	Cell Transformation, Neoplastic	Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	Neoplastic Transformation, Cell,Neoplastic Cell Transformation,Transformation, Neoplastic Cell,Tumorigenic Transformation,Cell Neoplastic Transformation,Cell Neoplastic Transformations,Cell Transformations, Neoplastic,Neoplastic Cell Transformations,Neoplastic Transformations, Cell,Transformation, Cell Neoplastic,Transformation, Tumorigenic,Transformations, Cell Neoplastic,Transformations, Neoplastic Cell,Transformations, Tumorigenic,Tumorigenic Transformations
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D015477	Leukemia, Myelomonocytic, Chronic	A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.	Myelomonocytic Leukemia, Chronic,Chronic Myelomonocytic Leukemia,Chronic Myelomonocytic Leukemias,Leukemia, Chronic Myelomonocytic,Leukemias, Chronic Myelomonocytic,Myelomonocytic Leukemias, Chronic
D054747	Histiocytic Sarcoma	Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.	Histiocytosis, Malignant,Malignant Histiocytosis,True Histiocytic Lymphoma,True Malignant Histiocytosis,Histiocytic Lymphoma, True,Histiocytic Lymphomas, True,Histiocytic Sarcomas,Histiocytoses, Malignant,Histiocytoses, True Malignant,Histiocytosis, True Malignant,Lymphoma, True Histiocytic,Lymphomas, True Histiocytic,Malignant Histiocytoses,Malignant Histiocytoses, True,Malignant Histiocytosis, True,Sarcoma, Histiocytic,Sarcomas, Histiocytic,True Histiocytic Lymphomas,True Malignant Histiocytoses