BIOMAT Database Logo BIOMAT Database Logo

Orally active hydroxamic acid inhibitors of leukotriene biosynthesis. 1988

J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Department 47K, Abbott Laboratories, Abbott Park, Illinois 60064.

UI MeSH Term Description Entries
D006877 Hydroxamic Acids A class of weak acids with the general formula R-CONHOH. Hydroxamic Acid,Acid, Hydroxamic,Acids, Hydroxamic
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013189 SRS-A A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed) Slow Reacting Substance of Anaphylaxis
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors.
September 1993, Agents and actions,
J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Inhibition of leukotriene biosynthesis and polymorphonuclear leukocyte functions by orally active quinolylmethoxyphenylamines.
February 1991, Pharmacology & toxicology,
J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Leukotriene biosynthesis inhibitors.
November 1985, Pharmaceutical research,
J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase.
October 1995, Bioorganic & medicinal chemistry,
J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.
January 1990, Journal of medicinal chemistry,
J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
May 1985, Journal of medicinal chemistry,
J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors.
February 2000, Journal of medicinal chemistry,
J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Hydroxamic acid inhibitors of 5-lipoxygenase.
March 1987, Journal of medicinal chemistry,
J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Antiallergic action of inhibitors of leukotriene biosynthesis.
January 1985, Advances in prostaglandin, thromboxane, and leukotriene research,
J B Summers, and B P Gunn, and J G Martin, and H Mazdiyasni, and A O Stewart, and P R Young, and A M Goetze, and J B Bouska, and R D Dyer, and D W Brooks
Synthesis of indolylalkoxyiminoalkylcarboxylates as leukotriene biosynthesis inhibitors.
March 1997, Bioorganic & medicinal chemistry,
Copied contents to your clipboard!