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The morpho-functional state of the muscle lymphoid tissue of mice treated with karmionmycin (LD50, 1.1 mg/kg) was studied experimentally. Development of a number of changes evident of the cell disorganization in the lymphoid tissue was shown. The cytological shifts in the thymus and spleen were reversible, while the destructive period in the strumous gland was more prolonged. The morpho-structural normalization of the spleen did not coincide with reduction of its immunological function. The studies on the karminomycin effect on the kinetics of the primary immune response showed dependence of the antibiotic effect on the temporal ratio between the antigenic stimulus and the drug administration. The antibiotic had no effect on the inductive phase of the primary immune response but significantly suppressed its productive phase. On reproduction of the secondary immune response, a decrease in the content of the antibody-forming cells in the spleen was observed, production of the circulating antibodies remaining unchanged.
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
January 1977,
Antibiotiki,
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
February 1981,
Gigiena i sanitariia,
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
October 1981,
Antibiotiki,
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
April 1957,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
January 1965,
Vestnik Akademii meditsinskikh nauk SSSR,
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
January 1996,
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993),
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
February 1973,
Gigiena i sanitariia,
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
March 1974,
Antibiotiki,
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
September 1978,
Gigiena i sanitariia,
E D Gol'dberg, and
T N Mikhaĭlova, and
G V Zinger, and
T S Shubina, and
Iu G Kozlova
September 1979,
Antibiotiki,
