Biomaterial Database

Immunosuppression of Clarias lazera (Pisces) by a molluscicide. 1988

M Faisal, and E L Cooper, and M el-Mofty, and M A Sayed

Faculty of Veterinary Medicine, University of Alexandria, Egypt.

Exposure of C. lazera to sublethal concentrations of the molluscicide, Bayluscide, for a 6-month period induced 14% (0.1 ppm) and 95% (0.3 ppm) mortalities. In addition, there was a depletion of hemopoeitic tissue in the mesonephros and spleen, an increased susceptibility to pathogens and appearance of nodules containing infectious organisms. Surviving fish produced lower titers of antibodies against injected antigens than controls and the number of corpuscles of Stannius increased in proportion to the concentration and duration of exposure to the Bayluscide. Long term exposure probably induced immunosuppression in C. lazera which caused these changes.

UI	MeSH Term	Description	Entries
D007107	Immune System	The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.	Immune Systems,System, Immune,Systems, Immune
D007166	Immunosuppressive Agents	Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.	Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D008975	Molluscacides	Agents destructive to snails and other mollusks.
D009534	Niclosamide	An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)	Bayer 2353,Bayer 73,Bayluscide,Clonitralide,Fenasal,Niclocide,Niclosamide, 2-Aminoethanol (1:1),Phenasal,Radewerm,Trédémine,Yomesan
D002397	Catfishes	Common name of the order Siluriformes. This order contains many families and over 2,000 species, including venomous species. Heteropneustes and Plotosus genera have dangerous stings and are aggressive. Most species are passive stingers.	Eremophilus mutisii,Heteropneustes,Plotosus,Siluriformes,Arius,Catfish,Colombian Catfish,Catfish, Colombian
D006413	Hematopoietic System	The blood-making organs and tissues, principally the bone marrow and lymph nodes.	Hematopoietic Systems,System, Hematopoietic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000917	Antibody Formation	The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.	Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody