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The induction of dominant cataract mutations by procarbazine was studied concomitantly with the induction of specific-locus mutations in treated male mice. The most effective dose in the specific-locus test, 600 mg/kg of procarbazine, and a fractionated dose of 5 X 200 mg/kg were used. The frequencies of dominant cataract mutations were higher, but not significantly different from the historical control. The ratio between the number of recovered specific-locus and dominant cataract mutations was in accordance with that found in our experiments with gamma-rays (Ehling et al., 1982; Kratochvilova, 1981) or in experiments with ethylnitrosourea (Favor, 1986). A total of 3 dominant cataract mutations were recovered in the offspring of procarbazine-treated spermatogonial stem cells. Two mutations had complete penetrance while the third exhibited a reduced penetrance of approximately 70%. The viability and fertility of the heterozygotes of all 3 mutations were not affected. Only 1 mutation was shown to be viable as a homozygote.
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
January 1986,
Mutation research,
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
January 1981,
The Journal of heredity,
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
February 1979,
Mutation research,
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
March 1987,
Mutation research,
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
August 1983,
Mutation research,
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
August 1986,
Mutation research,
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
May 1994,
Mutation research,
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
October 1989,
Mutation research,
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
August 1991,
Mutation research,
J Kratochvilova, and
J Favor, and
A Neuhäuser-Klaus
December 1998,
Genetical research,
