Formation of N-nitroso compounds under simulated gastric conditions from Kashmir foodstuffs. 1988

M Siddiqi, and A R Tricker, and R Preussmann
Department of Biochemistry, University of Kashmir, Srinagar, India.

Several foodstuffs and teas from an area of high esophageal cancer risk in Kashmir (India) were studied under simulated gastric conditions with a realistic nitrite concentration for the formation of N-nitroso compounds. N-Nitrosodimethylamine (NDMA), N-nitrosoproline (NPRO), N-nitrosothiazolidine-4-carboxylic acid (NTCA) and N-nitrosopipecolic acid (NPIC) were the main products in different foods. Significant amounts of NDMA were formed from dried fish (20 micrograms/kg), dried and pickled vegetables (35.6 micrograms/kg and 7.3 micrograms/kg), locally grown Brassica oleracea ('Hak') leaves (69.9 micrograms/kg), and the traditional tea 'Kehwa' (9.2 micrograms/kg). The highest level of NTCA was formed in smoked fish (3294 micrograms/kg). 'Salted tea' prepared according to local method formed considerable amounts of NPRO (360 micrograms/kg) and NPIC (5870 micrograms/kg) along with 3 yet unidentified non-volatile N-nitroso compounds. High values of 4315 micrograms/kg NPIC were also obtained following nitrosation of red chillies and mixed spice cake ('Wur') under simulated gastric conditions. These results suggest the possibility of an appreciable endogenous formation of N-nitroso compounds from local foods in Kashmir.

UI MeSH Term Description Entries
D007194 India A country in southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan. The capitol is New Delhi. Republic of India
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D009603 Nitroso Compounds Organic compounds containing the nitroso (-N Compounds, Nitroso
D005502 Food Substances taken in by the body to provide nourishment. Foods
D005504 Food Analysis Measurement and evaluation of the components of substances to be taken as FOOD. Analysis, Food,Analyses, Food,Food Analyses
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland

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