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Normal human platelets have been separated according to density on continuous Percoll gradients and the platelet distribution divided into five fractions containing approximately equal numbers of platelets. The mean volumes and protein contents of the platelets in each fraction were found to correlate positively with density while the protein concentration did not differ significantly between the fractions. Four mitochondrial enzymes (monoamine oxidase, glutamate dehydrogenase, cytochrome oxidase and NADP-dependent isocitrate dehydrogenase) were assayed and their activities per unit volume were found to increase in a very similar monotonic fashion with platelet density. When MAO and GDH were assayed on the same set of density fractions the correlation between the two activities was very high (r = 0.94-1.00, p less than 0.001) and a similar close correlation was found between MAO and ICDH. The results support the hypothesis that high density platelets either have a higher concentration of mitochondria or have larger mitochondria than low density platelets.
K G Chamberlain, and
D G Penington
April 1976,
Medical biology,
K G Chamberlain, and
D G Penington
October 1978,
Psychopharmacology,
K G Chamberlain, and
D G Penington
January 1981,
Psychopharmacology,
K G Chamberlain, and
D G Penington
January 1974,
Advances in biochemical psychopharmacology,
K G Chamberlain, and
D G Penington
July 1974,
Psychopharmacology bulletin,
K G Chamberlain, and
D G Penington
November 1981,
Biochemical pharmacology,
K G Chamberlain, and
D G Penington
October 1979,
Experientia,
K G Chamberlain, and
D G Penington
June 1977,
Biochemical pharmacology,
K G Chamberlain, and
D G Penington
January 1965,
Annales medicinae experimentalis et biologiae Fenniae,
K G Chamberlain, and
D G Penington
February 1970,
Nature,
