-transparent.png){kind=logo}
Platelet monoamine oxidase (MAO) activity was studied in three subpopulations of density-fractionated platelets in 15 unmedicated chronic paranoid schizophrenic patients and contrasted with normal controls. No significant difference in MAO activity was found in any of the three platelet fractions in schizophrenics compared to controls. Enzyme kinetic studies performed on the intermediate-density platelet fraction demonstrated no significant differences in Vmax or Michaelis' constant (Km) between schizophrenics and controls, but showed that the higher platelet MAO activity reported in females compared to male is due to a significantly greater Vmax rather than altered Km. It is suggested that conflicting results reported in the literature regarding platelet MAO in schizophrenia are not related to the platelet subpopulations studied but are largely due to the selected patient populations.
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
February 1988,
Thrombosis and haemostasis,
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
August 1986,
Neuroscience letters,
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
January 1986,
Biological psychiatry,
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
July 1975,
Psychopharmacology bulletin,
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
October 1978,
Psychopharmacology,
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
June 1981,
Archives of general psychiatry,
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
April 2014,
Journal of neural transmission (Vienna, Austria : 1996),
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
January 1980,
Schizophrenia bulletin,
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
November 1981,
Biochemical pharmacology,
J J Mann, and
R D Kaplan, and
A Georgotas, and
E Friedman, and
M Branchey, and
S Gershon
November 1975,
National Institute on Drug Abuse research monograph series,
