Biomaterial Database

Oral absorption of pivampicillin and ampicillin in young children: cross-over study using equimolar doses of a suspension. 1977

L Pedersen-Bjergaard, and K E Petersen

In a cross-over study, the oral absorption following equimolar doses of ampicillin corresponding to 16.7 mg/kg administrered as pivampicillin ('Pondocillin') suspension and ampicillin ('Doktacillin') suspension respectively, was investigated in 11 children aged from 8 months to 4.5 years. Pivampicillin produced a mean peak serum concentration of 10.7 microgram ampicillin/ml compared with 5.8 microgram/ml after ampicillin. The mean area under the serum concentration-time curves was 29.2 microgram/ml-h after pivampicillin and 16.7 microgram/ml-h after ampicillin, reflecting the superior bioavailability of the ester form. In 4 of the children aged between 8 and 12 months, the serum levels after pivampicillin were consistenly lower than those recorded in the remaining 7 children beyound the age of 1 year. The mechanism and therapeutic implications of this finding require further study.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D008297	Male		Males
D010917	Pivampicillin	Pivalate ester analog of AMPICILLIN.	Ampicillin Pivaloyl Ester,Berocillin,Pivamiser,Pivampicillin Hydrochloride,Pivampicillin Monohydrochloride,Pondocillin,Ester, Ampicillin Pivaloyl,Hydrochloride, Pivampicillin,Monohydrochloride, Pivampicillin
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000667	Ampicillin	Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.	Penicillin, Aminobenzyl,Amcill,Aminobenzylpenicillin,Ampicillin Sodium,Ampicillin Trihydrate,Antibiotic KS-R1,Omnipen,Pentrexyl,Polycillin,Ukapen,Aminobenzyl Penicillin,Antibiotic KS R1,KS-R1, Antibiotic,Sodium, Ampicillin,Trihydrate, Ampicillin