Calcium regulation by and buffer capacity of molluscan neurons during calcium transients. 1988

Z Ahmed, and J A Connor
Department of Physiology, State University of New York, Buffalo.

The properties of Ca-regulation and -buffering of physiological levels of Ca-transients were examined in the soma of Archidoris monteryensis neurons. The rate of recovery from a Ca-transient was examined with two experimental protocols; in one the pulse duration was kept constant and its amplitude was varied, and in the other the duration was varied while the amplitude was kept constant. These experiments revealed that the recovery from a Ca-transient was approximately a first order process and the apparent first order rate constant was dependent on the duration of Ca-influx. The calcium buffer capacity of the cytoplasm was determined by an indirect method which utilised measured amounts of intracellular EGTA to reduce transient changes in free calcium. An equation for the cytoplasmic buffer capacity was derived on the assumption that the capacities of exogenous and endogenous Ca buffers summate linearly. The resting cytoplasmic Ca buffer capacity was 45.2 microM/delta pCa, when it was assumed that the incoming Ca diffuses a distance of 10 microns into the cytoplasm. For a diffusion distance of 5 microns it was 34.5 microM/delta pCa. In both cases, the buffer capacity increased with an increase in the size of Ca transient.

UI MeSH Term Description Entries
D008974 Mollusca A phylum of the kingdom Metazoa. Mollusca have soft, unsegmented bodies with an anterior head, a dorsal visceral mass, and a ventral foot. Most are encased in a protective calcareous shell. It includes the classes GASTROPODA; BIVALVIA; CEPHALOPODA; Aplacophora; Scaphopoda; Polyplacophora; and Monoplacophora. Molluscs,Mollusks,Mollusc,Molluscas,Mollusk
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002021 Buffers A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer. Buffer
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D003593 Cytoplasm The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990) Protoplasm,Cytoplasms,Protoplasms
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001150 Arsenazo III Metallochrome indicator that changes color when complexed to the calcium ion under physiological conditions. It is used to measure local calcium ion concentrations in vivo.

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