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Biodistribution, kinetics and dosimetry of 9Tcm-albumin colloid labeled leukocytes (TAC-WBC) is described. A practical method of planar image data acquisition and processing is discussed. This method was used to obtain biodistribution data in 11 patients, two of whom were children. Dosimetry was calculated for fetuses, children and adults. The spleen is the critical organ, receiving 2.5 rad per 5 mCi procedure in adults and 3.6 rad per 2.15 mCi procedure in a 5-year-old child. These absorbed doses are about one-sixth of that absorbed from 111In-leukocytes procedures utilizing one-tenth the administered activity of TAC-WBC. The liver and red marrow are approximately equivalent secondary target organs, each receiving about 20% of the spleen dose. Fetal doses at any stage of gestation are similar, averaging about 14 mrad per mCi of TAC-WBC administered to the mother. The dosimetry of TAC-WBC is favorable enough to permit its use in children, adults and during pregnancy.
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J A Butler, and
J H Kuperus
November 1990,
Nuclear medicine communications,
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Nuclear medicine communications,
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C S Marcus, and
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C S Marcus, and
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C S Marcus, and
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August 1977,
Radiology,
C S Marcus, and
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December 2005,
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...,
C S Marcus, and
M G Stabin, and
E E Watson, and
P L Henneman, and
J A Butler, and
J H Kuperus
April 1978,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
C S Marcus, and
M G Stabin, and
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J H Kuperus
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Nuclear medicine communications,
C S Marcus, and
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J H Kuperus
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Nuclear medicine communications,
