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Amino acid requirements of Staphylococcus aureus strains from Germany and Austria that produce toxic shock syndrome toxin-1 (TSST-1). 1988

N Dickgiesser, and P Eppli
Institut für Hygiene und Medizinische Mikrobiologie, Fakultät für Klinische Medizin, Mannheim der Universität Heidelberg.

Amino acid requirements of 156 toxic shock syndrome toxin-1 (TSST-1) producing Staphylococcus aureus strains from Germany and 37 strains from Austria have been determined. They were compared with TSST-1 negative S. aureus. Most of the strains required proline and valine with no significant differences between TSST-1 positive and negative S. aureus. There was no correlation between tryptophan auxotypy and TSST-1 producing strains. On complete chemically defined medium good bacterial growth was usually observed. Nevertheless, many strains stopped toxin production under these conditions. S. aureus strains with TSST-1 synthesis on complete medium required phenylalanine and cysteine for TSST-1 production mainly.

UI MeSH Term Description Entries
D004768 Enterotoxins Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria. Staphylococcal Enterotoxin,Enterotoxin,Staphylococcal Enterotoxins,Enterotoxin, Staphylococcal,Enterotoxins, Staphylococcal
D005860 Germany, West The former Federal Republic of Germany which was reunified with the former German Democratic Republic in 1990. Federal Republic of Germany,Germany, Federal Republic of
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D001317 Austria A country located in Central Europe, north of Italy and Slovenia. The capital is Vienna.
D001427 Bacterial Toxins Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases. Bacterial Toxin,Toxins, Bacterial,Toxin, Bacterial
D013045 Species Specificity The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species. Species Specificities,Specificities, Species,Specificity, Species
D013211 Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
D018089 Superantigens Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions. Superantigen

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