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The pharmacokinetics of midazolam were compared in cirrhotic patients (n = 10) and control patients (n = 9), during general anaesthesia. Total plasma clearance was 637 +/- 223 ml min-1 (mean +/- SD) in control patients and 402 +/- 170 ml min-1 in cirrhotic patients (P less than 0.05). The total volume of distribution was similar. Elimination half-life was 135 +/- 40 min in controls and 168 +/- 30 min in cirrhosis (P less than 0.05). Protein binding was evaluated by equilibrium dialysis in both groups at two concentrations of midazolam: 20 and 500 micrograms litre-1. No saturation occurred, but the free fraction was 4.9 +/- 1.7% in cirrhotic patients, compared with 1.9 +/- 0.6% in controls (P less than 0.01). Despite its mainly hepatic elimination, midazolam disposition appears to be only slightly impaired in cirrhotic patients.
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
January 2020,
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology,
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
April 1991,
Arzneimittel-Forschung,
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
December 1982,
British journal of anaesthesia,
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
January 1989,
European journal of clinical pharmacology,
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
January 1985,
Therapie,
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
December 1993,
Critical care medicine,
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
January 2000,
European journal of drug metabolism and pharmacokinetics,
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
September 1985,
British journal of anaesthesia,
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
May 1987,
British journal of clinical pharmacology,
J H Trouvin, and
R Farinotti, and
J P Haberer, and
F Servin, and
M Chauvin, and
P Duvaldestin
June 2003,
The American journal of gastroenterology,
