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The pharmacokinetics of phenoperidine have been studied in five anaesthetized patients receiving a 2-mg bolus dose i.v. Plasma concentrations were measured using a sensitive radioimmunoassay method. The distribution of phenoperidine was described according to a two-compartment open model. The mean distribution half-life (T1/2 alpha) for the five patients was short (2.2 min); the mean elimination half-life (T1/2 beta) was 193 min. The mean whole body clearance was 22 ml min-1 kg-1 and the apparent steady state distribution volume (VSS) was 5.7 litre kg-1. Secondary concentration peaks occurred in all patients; in two patients these were substantial and occurred 80 min after injection.
M Fischler, and
J C Levron, and
H Trang, and
J F Vaxelaire, and
B Flaisler, and
G Vourc'h
January 2023,
Frontiers in pharmacology,
M Fischler, and
J C Levron, and
H Trang, and
J F Vaxelaire, and
B Flaisler, and
G Vourc'h
July 1986,
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M Fischler, and
J C Levron, and
H Trang, and
J F Vaxelaire, and
B Flaisler, and
G Vourc'h
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G Vourc'h
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M Fischler, and
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J F Vaxelaire, and
B Flaisler, and
G Vourc'h
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J C Levron, and
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G Vourc'h
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M Fischler, and
J C Levron, and
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G Vourc'h
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M Fischler, and
J C Levron, and
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B Flaisler, and
G Vourc'h
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M Fischler, and
J C Levron, and
H Trang, and
J F Vaxelaire, and
B Flaisler, and
G Vourc'h
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M Fischler, and
J C Levron, and
H Trang, and
J F Vaxelaire, and
B Flaisler, and
G Vourc'h
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