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The long-term stability of transcription complexes on 5S RNA genes has been demonstrated in vivo. Complexes on oocyte and somatic-type 5S RNA genes injected into Xenopus laevis oocyte nuclei are stable for at least 4 days. Tissue culture cells and mature erythrocytes have equivalent numbers of somatic 5S RNA genes programmed into transcription complexes, yet the former cell type has a greater than 50-fold higher cellular content of transcription factor IIIA (TFIIIA). Functional transcription complexes on somatic 5S RNA genes in nucleated erythrocytes of Xenopus are stable for weeks, perhaps months, even though a mature erythrocyte has less than two molecules of TFIIIA for each somatic 5S RNA gene. These findings strengthen our proposal that stable transcription complexes are a means of maintaining the differentiated state.
M K Darby, and
M T Andrews, and
D D Brown
February 1982,
Cell,
M K Darby, and
M T Andrews, and
D D Brown
January 1982,
Nature,
M K Darby, and
M T Andrews, and
D D Brown
July 1984,
Cell,
M K Darby, and
M T Andrews, and
D D Brown
October 1979,
Nucleic acids research,
M K Darby, and
M T Andrews, and
D D Brown
January 1983,
Cold Spring Harbor symposia on quantitative biology,
M K Darby, and
M T Andrews, and
D D Brown
May 2001,
Molecular and cellular biology,
M K Darby, and
M T Andrews, and
D D Brown
January 1979,
Proceedings of the National Academy of Sciences of the United States of America,
M K Darby, and
M T Andrews, and
D D Brown
September 1988,
Nucleic acids research,
M K Darby, and
M T Andrews, and
D D Brown
November 1978,
Cell,
M K Darby, and
M T Andrews, and
D D Brown
May 1993,
Developmental biology,
