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The properties of active and repressed 5S rna genes in somatic cell chromatin from Xenopus laevis cultured cells were studied by transcription in vitro. The somatic 5S RNA genes, which are active in vivo, are packaged in chromatin as active stable transcription complexes lacking only RNA polymerase III for transcription activity. The oocyte 5S RNA genes, which are inactive in somatic tissues, do not have transcription factors bound to them in purified chromatin and are prevented from binding these factors by a structure dependent on histone H1. In chromatin active stable transcription complexes protect 5S RNA genes from histone H1-mediated repression and H1 binding prevents the formation of stable active transcription complexes.
M S Schlissel, and
D D Brown
August 1988,
Proceedings of the National Academy of Sciences of the United States of America,
M S Schlissel, and
D D Brown
February 1982,
Cell,
M S Schlissel, and
D D Brown
May 1994,
Genes & development,
M S Schlissel, and
D D Brown
February 1989,
The EMBO journal,
M S Schlissel, and
D D Brown
July 1998,
Molecular and cellular biology,
M S Schlissel, and
D D Brown
January 1977,
Proceedings of the National Academy of Sciences of the United States of America,
M S Schlissel, and
D D Brown
October 1979,
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M S Schlissel, and
D D Brown
July 1990,
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M S Schlissel, and
D D Brown
May 1998,
Biochemistry,
