-transparent.png){kind=logo}
Multimodal prognosis of negative symptom severity in individuals at increased risk of developing psychosis. 2021
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. daniel.hauke@unibas.ch.
Negative symptoms occur frequently in individuals at clinical high risk (CHR) for psychosis and contribute to functional impairments. The aim of this study was to predict negative symptom severity in CHR after 9 months. Predictive models either included baseline negative symptoms measured with the Structured Interview for Psychosis-Risk Syndromes (SIPS-N), whole-brain gyrification, or both to forecast negative symptoms of at least moderate severity in 94 CHR. We also conducted sequential risk stratification to stratify CHR into different risk groups based on the SIPS-N and gyrification model. Additionally, we assessed the models' ability to predict functional outcomes in CHR and their transdiagnostic generalizability to predict negative symptoms in 96 patients with recent-onset psychosis (ROP) and 97 patients with recent-onset depression (ROD). Baseline SIPS-N and gyrification predicted moderate/severe negative symptoms with significant balanced accuracies of 68 and 62%, while the combined model achieved 73% accuracy. Sequential risk stratification stratified CHR into a high (83%), medium (40-64%), and low (19%) risk group regarding their risk of having moderate/severe negative symptoms at 9 months follow-up. The baseline SIPS-N model was also able to predict social (61%), but not role functioning (59%) at above-chance accuracies, whereas the gyrification model achieved significant accuracies in predicting both social (76%) and role (74%) functioning in CHR. Finally, only the baseline SIPS-N model showed transdiagnostic generalization to ROP (63%). This study delivers a multimodal prognostic model to identify those CHR with a clinically relevant negative symptom severity and functional impairments, potentially requiring further therapeutic consideration.
Related Publications
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
January 2013,
Psychiatry research,
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
December 2018,
Schizophrenia research,
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
March 2015,
Schizophrenia research,
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
July 2017,
Acta psychiatrica Scandinavica,
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
January 2015,
Psychopathology,
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
August 2014,
Human brain mapping,
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
October 2018,
Early intervention in psychiatry,
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
April 2012,
Psychiatry research,
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
August 2021,
Early intervention in psychiatry,
Daniel J Hauke, and
André Schmidt, and
Erich Studerus, and
Christina Andreou, and
Anita Riecher-Rössler, and
Joaquim Radua, and
Joseph Kambeitz, and
Anne Ruef, and
Dominic B Dwyer, and
Lana Kambeitz-Ilankovic, and
Theresa Lichtenstein, and
Rachele Sanfelici, and
Nora Penzel, and
Shalaila S Haas, and
Linda A Antonucci, and
Paris Alexandros Lalousis, and
Katharine Chisholm, and
Frauke Schultze-Lutter, and
Stephan Ruhrmann, and
Jarmo Hietala, and
Paolo Brambilla, and
Nikolaos Koutsouleris, and
Eva Meisenzahl, and
Christos Pantelis, and
Marlene Rosen, and
Raimo K R Salokangas, and
Rachel Upthegrove, and
Stephen J Wood, and
Stefan Borgwardt, and
January 2022,
Early intervention in psychiatry,
