Stimulus conditions were examined where both across-frequency [comodulation masking release (CMR)] and across-ear [binaural masking-level difference (BMLD)] cues were available, as well as conditions where only one of these cue types was available. The main goal of the study was to determine how the two types of cues combine. The effects of comodulation were assessed either by modulating a masking noise and manipulating its bandwidth (experiment 1) or by using two comodulated narrow bands of noise separated in frequency (experiment 2). The masker was always No, and the 500-Hz pure-tone signal was either So or S pi. The effect of the frequency of modulation was examined either by changing the frequency of the modulating stimulus (experiment 1) or by changing the bandwidth of the comodulated narrow-band noise (experiment 2). Four of six subjects showed greater masking release when both BMLD and CMR cues were available than for either type of cue alone, whereas the other two subjects did not show an ability to combine the two cues for additional advantage. For the subjects who were able to combine the two types of cue, the additional advantage was greater for low frequencies of modulation. The results indicate that one component of CMR may be based upon across-frequency envelope comparisons at a stage of processing after binaural analysis.