Biomaterial Database

Insect repellent, N,N-diethyl-m-toluamide, effect on ammonia metabolism. 1988

H M Heick, and R G Peterson, and M Dalpe-Scott, and I A Qureshi

Research Institute of the Children's Hospital of Eastern Ontario, Ottawa, Canada.

There appear to be at least three mechanisms for systemic reactions to diethyltoluamide. As with most substances, allergy is possible. The ingestion of large doses can produce seizures and coma by a direct action on the CNS. This occurs in experimental animals in which seizures and coma followed by death can be produced rapidly if sufficiently large doses are given. Finally, with smaller systemic doses as may occur with absorption during heavy topical use, there is also the possibility of a perturbation of ammonia metabolism. Diethyltoluamide may then pose a substantial hazard to individuals with defects in ammonia metabolism.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D003671	DEET	A compound used as a topical insect repellent that may cause irritation to eyes and mucous membranes, but not to the skin.	DEET, 2,5-di-Me-Analog,DET,DETA,N,N-Diethyl-2,5-dimethylbenzamide,N,N-Diethyl-3-methylbenzamide,N,N-Diethyl-m-toluamide,N,N-Diethyltoluamide,R-209,N,N Diethyl 3 methylbenzamide,N,N Diethyl m toluamide,N,N Diethyltoluamide,R 209,R209
D000641	Ammonia	A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001549	Benzamides	BENZOIC ACID amides.
D014474	Unconsciousness	Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)	Consciousness, Loss of,Unconscious State,Loss of Consciousness,State, Unconscious,Unconscious States
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus