-transparent.png){kind=logo}
Flavone acetic acid pharmacokinetics were studied in 31 patients in a phase I clinical trial. The drug was given by i.v. infusions over 1, 1.5, 3, and 6 h at doses ranging from 0.5 to 6.4 g/m2. The pharmacokinetic parameters were determined according to a nonlinear model including Michaelis-Menten-type kinetics. The mean elimination half-life is 4.8 h and the mean volume of distribution of the central compartment, 7.61. Our model predicted a maximal tolerated dose (MTD) of 11.1 g/m2 on the basis of the "therapeutic window" concept, very close to the clinically observed MTD of 10 g/m2. This model is also operational when different protocols of inoculation are considered, such as a divided-dose schedule vs a unique infusion, and indicates that, at the MTD, injections should be made every 72 h to avoid drug accumulation.
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
December 1987,
Cancer research,
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
January 1991,
Journal of the National Cancer Institute,
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
June 1986,
Cancer research,
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
January 1992,
Cancer chemotherapy and pharmacology,
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
October 1990,
Cancer research,
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
November 1989,
British journal of cancer,
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
September 1989,
European journal of cancer & clinical oncology,
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
January 1989,
Bulletin du cancer,
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
January 1990,
Cancer chemotherapy and pharmacology,
A Gouyette, and
D J Kerr, and
S B Kaye, and
A Setanoians, and
J Cassidy, and
C Bradley, and
G Forrest, and
M Soukop
January 1990,
Anticancer research,
