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1. Isolated rat hepatocytes were exposed to the fumigant 1,2-dibromoethane (DBE) and cytotoxicity was evaluated by studying parameters of cellular function and lipid peroxidation. 2. DBE caused plasma membrane damage, as determined by leakage of lactate dehydrogenase, and was more severe in shaken suspensions than stationary suspensions, suggesting that cells were more fragile after DBE exposure. 3. DBE decreased hepatocyte glycogen content and stimulated albumin synthesis in hepatocyte suspensions. 4. Lipid peroxidation resulted from DBE exposure and was greater in cells isolated from phenobarbital-pretreated rats. Shaking the suspensions enhanced lipid peroxidation. Ethane production did not parallel formation of thiobarbituric acid reactants, suggesting that these parameters of lipid peroxidation reflect different mechanisms of molecular interaction of DBE.
A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
August 1984,
Chemico-biological interactions,
A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
September 1991,
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A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
January 1975,
European journal of biochemistry,
A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
November 1986,
Biochimica et biophysica acta,
A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
November 1980,
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A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
May 2001,
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A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
May 1982,
Research communications in chemical pathology and pharmacology,
A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
February 1988,
Nihon juigaku zasshi. The Japanese journal of veterinary science,
A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
November 1981,
Lipids,
A A van Iersel, and
I van Holsteijn, and
B J Blaauboer
November 1975,
European journal of biochemistry,
