BIOMAT Database Logo BIOMAT Database Logo

Inhibition of theophylline elimination by diltiazem therapy. 1987

A N Nafziger, and J J May, and J S Bertino
Department of Medicine, Mary Imogene Bassett Hospital, Cooperstown, New York 13326.

To investigate the effects of diltiazem on theophylline pharmacokinetics, nine healthy male subjects (four smokers and five nonsmokers) received intravenous aminophylline (6 mg/kg) prior to and following 10 days of oral diltiazem therapy. Theophylline half-life increased significantly whereas total body clearance showed a significant decrease following diltiazem. Volume of distribution was unchanged. The small group of smokers had a significantly greater increase in theophylline half-life than the nonsmokers. Inhibition of metabolism of theophylline by diltiazem likely explains the significant changes in theophylline pharmacokinetics. A clinically important drug interaction may occur with theophylline when diltiazem therapy is given concurrently.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D004110 Diltiazem A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions. Aldizem,CRD-401,Cardil,Cardizem,Dilacor,Dilacor XR,Dilren,Diltiazem Hydrochloride,Diltiazem Malate,Dilzem,Tiazac,CRD 401,CRD401
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000628 Aminophylline A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications. Afonilum,Aminodur,Aminophyllin,Aminophylline DF,Cardophyllin,Carine,Clonofilin,Corophyllin,Diaphyllin,Drafilyn,Duraphyllin,Eufilina,Eufilina Venosa,Euphyllin,Euphyllin Retard,Euphylline,Godafilin,Mini-Lix,Mundiphyllin,Mundiphyllin Retard,Novophyllin,Phyllocontin,Phyllotemp,Somophyllin,Tari-Dog,Theophyllamin Jenapharm,Theophyllamine,Theophyllin EDA-ratiopharm,Theophylline Ethylenediamine,Truphylline,Ethylenediamine, Theophylline,Theophyllin EDA ratiopharm,Theophyllin EDAratiopharm
D012907 Smoking Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand. Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits
D013806 Theophylline A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP. 1,3-Dimethylxanthine,3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione,Accurbron,Aerobin,Aerolate,Afonilum Retard,Aquaphyllin,Armophylline,Bronchoparat,Bronkodyl,Constant-T,Elixophyllin,Euphylong,Glycine Theophyllinate,Lodrane,Monospan,Nuelin,Nuelin S.A.,Quibron T-SR,Slo-Phyllin,Somophyllin-T,Sustaire,Synophylate,Theo Von Ct,Theo-24,Theo-Dur,Theobid,Theocin,Theoconfin Continuous,Theodur,Theolair,Theolix,Theon,Theonite,Theopek,Theophylline Anhydrous,Theophylline Sodium Glycinate,Theospan,Theostat,Theovent,Uniphyl,Uniphyllin,Uniphylline,1,3 Dimethylxanthine,Anhydrous, Theophylline,Constant T,ConstantT,Ct, Theo Von,Glycinate, Theophylline Sodium,Quibron T SR,Quibron TSR,Slo Phyllin,SloPhyllin,Sodium Glycinate, Theophylline,Somophyllin T,SomophyllinT,Theo 24,Theo Dur,Theo24,Theophyllinate, Glycine,Von Ct, Theo

Related Publications

A N Nafziger, and J J May, and J S Bertino
Inhibition of theophylline elimination in rabbits by verapamil.
April 1989, Pharmacology & toxicology,
A N Nafziger, and J J May, and J S Bertino
Time-dependent inhibition of theophylline elimination by erythromycin stearate.
January 1986, Biopharmaceutics & drug disposition,
A N Nafziger, and J J May, and J S Bertino
Diltiazem treatment impairs theophylline elimination in patients with bronchospastic airway disease.
February 1994, Therapeutic drug monitoring,
A N Nafziger, and J J May, and J S Bertino
Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans.
March 1988, The Journal of pharmacology and experimental therapeutics,
A N Nafziger, and J J May, and J S Bertino
Verapamil-induced inhibition of theophylline elimination in healthy humans.
February 1990, Pharmacology & toxicology,
A N Nafziger, and J J May, and J S Bertino
Depression of theophylline elimination by erythromycin.
September 1981, Clinical pharmacology and therapeutics,
A N Nafziger, and J J May, and J S Bertino
Postanesthetic theophylline elimination.
April 1986, Anesthesia and analgesia,
A N Nafziger, and J J May, and J S Bertino
Nonlinear theophylline elimination.
March 1982, Clinical pharmacology and therapeutics,
A N Nafziger, and J J May, and J S Bertino
Absorption inhibition and enhancement of elimination of sustained-release theophylline tablets by oral activated charcoal.
November 1986, Annals of emergency medicine,
A N Nafziger, and J J May, and J S Bertino
Elimination of unstable angina by diltiazem under temporary pacing.
November 1984, Clinical cardiology,
Copied contents to your clipboard!