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The elimination of a single oral dose of theophylline was studied in 12 healthy subjects before and after 250 mg erythromycin every 8 hr for 10 days. Serum theophylline elimination half-life rose from 4.79 +/- 0.43 hr before to 7.53 +/- 0.71 hr after erythromycin. Theophylline clearance decreased from a mean of 91.6 +/- 27.0 to 54.8 +/- 10.0 ml/kg/hr after erythromycin and the mean apparent volumes of distribution were much the same before and after the antibiotic. The excretion of theophylline and its metabolites was studied in the urine of three of the subjects. In each case the amount of 3-methylxanthine and 1,3-dimethyluric acid decreased after antibiotic. Adjustments of the theophylline dosage may be necessary for patients who take theophylline and erythromycin concurrently to minimize the risk of theophylline toxicity.
K W Renton, and
J D Gray, and
O R Hung
June 1981,
Biochemical pharmacology,
K W Renton, and
J D Gray, and
O R Hung
January 1986,
Biopharmaceutics & drug disposition,
K W Renton, and
J D Gray, and
O R Hung
January 1982,
Journal of clinical pharmacology,
K W Renton, and
J D Gray, and
O R Hung
January 1988,
The Journal of asthma : official journal of the Association for the Care of Asthma,
K W Renton, and
J D Gray, and
O R Hung
September 1983,
Chest,
K W Renton, and
J D Gray, and
O R Hung
November 1987,
Journal of clinical pharmacology,
K W Renton, and
J D Gray, and
O R Hung
February 1978,
Pediatrics,
K W Renton, and
J D Gray, and
O R Hung
April 1986,
Anesthesia and analgesia,
K W Renton, and
J D Gray, and
O R Hung
March 1982,
Clinical pharmacology and therapeutics,
K W Renton, and
J D Gray, and
O R Hung
December 1981,
The Journal of allergy and clinical immunology,
