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Production and Supply of α-Particle-Emitting Radionuclides for Targeted α-Therapy. 2021
Valery Radchenko, and
Alfred Morgenstern, and
Amir R Jalilian, and
Caterina F Ramogida, and
Cathy Cutler, and
Charlotte Duchemin, and
Cornelia Hoehr, and
Ferrid Haddad, and
Frank Bruchertseifer, and
Haavar Gausemel, and
Hua Yang, and
Joao Alberto Osso, and
Kohshin Washiyama, and
Kenneth Czerwinski, and
Kirsten Leufgen, and
Marek Pruszyński, and
Olga Valzdorf, and
Patrick Causey, and
Paul Schaffer, and
Randy Perron, and
Samsonov Maxim, and
D Scott Wilbur, and
Thierry Stora, and
Yawen Li
Life Sciences Division, TRIUMF, Vancouver, British Columbia, Canada; vradchenko@triumf.ca.
Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present review, we discuss the most promising candidates for clinical application and the state of the art of their production and supply. In this review, along with 2 forthcoming reviews on chelation and clinical application of α-emitting radionuclides, The Journal of Nuclear Medicine will provide a comprehensive assessment of the field.
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