Wireless, battery-free, subdermally implantable platforms for transcranial and long-range optogenetics in freely moving animals. 2021

Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
Department of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721.

Wireless, battery-free, and fully subdermally implantable optogenetic tools are poised to transform neurobiological research in freely moving animals. Current-generation wireless devices are sufficiently small, thin, and light for subdermal implantation, offering some advantages over tethered methods for naturalistic behavior. Yet current devices using wireless power delivery require invasive stimulus delivery, penetrating the skull and disrupting the blood-brain barrier. This can cause tissue displacement, neuronal damage, and scarring. Power delivery constraints also sharply curtail operational arena size. Here, we implement highly miniaturized, capacitive power storage on the platform of wireless subdermal implants. With approaches to digitally manage power delivery to optoelectronic components, we enable two classes of applications: transcranial optogenetic activation millimeters into the brain (validated using motor cortex stimulation to induce turning behaviors) and wireless optogenetics in arenas of more than 1 m2 in size. This methodology allows for previously impossible behavioral experiments leveraging the modern optogenetic toolkit.

UI MeSH Term Description Entries
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D059015 Wireless Technology Techniques using energy such as radio frequency, infrared light, laser light, visible light, or acoustic energy to transfer information without the use of wires, over both short and long distances. Technologies, Wireless,Technology, Wireless,Wireless Technologies
D062308 Optogenetics The combination of genetic and optical methods in controlling specific events with temporal precision in targeted cells of a functioning intact biological system. Optogenetic Techniques,Optogenetic,Optogenetic Technique,Technique, Optogenetic,Techniques, Optogenetic
D019736 Prostheses and Implants Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally. Implants, Artificial,Prostheses and Implant,Prosthesis,Prosthetic Implant,Endoprostheses,Endoprosthesis,Prostheses,Prosthetic Implants,Artificial Implant,Artificial Implants,Implant and Prostheses,Implant, Artificial,Implant, Prosthetic,Implants and Prostheses,Implants, Prosthetic
D065908 Transcranial Direct Current Stimulation A technique of brain electric stimulation therapy which uses constant, low current delivered via ELECTRODES placed on various locations on the scalp. Anodal Stimulation Transcranial Direct Current Stimulation,Anodal Stimulation tDCS,Cathodal Stimulation Transcranial Direct Current Stimulation,Cathodal Stimulation tDCS,Repetitive Transcranial Electrical Stimulation,Transcranial Alternating Current Stimulation,Transcranial Electrical Stimulation,Transcranial Random Noise Stimulation,tDCS,Anodal Stimulation tDCSs,Cathodal Stimulation tDCSs,Electrical Stimulation, Transcranial,Electrical Stimulations, Transcranial,Stimulation tDCS, Anodal,Stimulation tDCS, Cathodal,Stimulation tDCSs, Anodal,Stimulation tDCSs, Cathodal,Stimulation, Transcranial Electrical,Stimulations, Transcranial Electrical,Transcranial Electrical Stimulations,tDCS, Anodal Stimulation,tDCS, Cathodal Stimulation,tDCSs, Anodal Stimulation,tDCSs, Cathodal Stimulation

Related Publications

Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
January 2021, Microsystems & nanoengineering,
Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
February 2022, Science advances,
Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
November 2017, Pain,
Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
February 2020, Proceedings of the National Academy of Sciences of the United States of America,
Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
January 2013, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
January 2013, Journal of neuroscience methods,
Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
January 2021, Frontiers in neuroscience,
Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
April 2021, Biosensors & bioelectronics,
Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
April 2011, IEEE transactions on biomedical circuits and systems,
Jokubas Ausra, and Mingzheng Wu, and Xin Zhang, and Abraham Vázquez-Guardado, and Patrick Skelton, and Roberto Peralta, and Raudel Avila, and Thomas Murickan, and Chad R Haney, and Yonggang Huang, and John A Rogers, and Yevgenia Kozorovitskiy, and Philipp Gutruf
February 2011, Nature neuroscience,
Copied contents to your clipboard!