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Wireless, battery-free push-pull microsystem for membrane-free neurochemical sampling in freely moving animals. 2022

Guangfu Wu, and Ian Heck, and Nannan Zhang, and Glenn Phaup, and Xincheng Zhang, and Yixin Wu, and David E Stalla, and Zhengyan Weng, and He Sun, and Huijie Li, and Zhe Zhang, and Shinghua Ding, and De-Pei Li, and Yi Zhang
Department of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.

Extensive studies in both animals and humans have demonstrated that high molecular weight neurochemicals, such as neuropeptides and other polypeptide neurochemicals, play critical roles in various neurological disorders. Despite many attempts, existing methods are constrained by detecting neuropeptide release in small animal models during behavior tasks, which leaves the molecular mechanisms underlying many neurological and psychological disorders unresolved. Here, we report a wireless, programmable push-pull microsystem for membrane-free neurochemical sampling with cellular spatial resolution in freely moving animals. In vitro studies demonstrate the sampling of various neurochemicals with high recovery (>80%). Open-field tests reveal that the device implantation does not affect the natural behavior of mice. The probe successfully captures the pharmacologically evoked release of neuropeptide Y in freely moving mice. This wireless push-pull microsystem creates opportunities for neuroscientists to understand where, when, and how the release of neuropeptides modulates diverse behavioral outputs of the brain.

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