Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo. 2021

Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Increasing evidence suggests natriuretic peptides (NPs) coordinate inter-organ metabolic crosstalk with adipose tissues and play a critical role in energy metabolism. We recently reported A-type NP (ANP) raises intracellular temperature in cultured adipocytes in a low-temperature-sensitive manner. We herein investigated whether exogenous ANP-treatment exerts a significant impact on adipose tissues in vivo. Mice fed a high-fat-diet (HFD) or normal-fat-diet (NFD) for 13 weeks were treated with or without ANP infusion subcutaneously for another 3 weeks. ANP-treatment significantly ameliorated HFD-induced insulin resistance. HFD increased brown adipose tissue (BAT) cell size with the accumulation of lipid droplets (whitening), which was suppressed by ANP-treatment (re-browning). Furthermore, HFD induced enlarged lipid droplets in inguinal white adipose tissue (iWAT), crown-like structures in epididymal WAT, and hepatic steatosis, all of which were substantially attenuated by ANP-treatment. Likewise, ANP-treatment markedly increased UCP1 expression, a specific marker of BAT, in iWAT (browning). ANP also further increased UCP1 expression in BAT with NFD. Accordingly, cold tolerance test demonstrated ANP-treated mice were tolerant to cold exposure. In summary, exogenous ANP administration ameliorates HFD-induced insulin resistance by attenuating hepatic steatosis and by inducing adipose tissue browning (activation of the adipose tissue thermogenic program), leading to in vivo thermogenesis during cold exposure.

UI MeSH Term Description Entries
D007333 Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. Insulin Sensitivity,Resistance, Insulin,Sensitivity, Insulin
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009320 Atrial Natriuretic Factor A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS. ANF,ANP,Atrial Natriuretic Peptide,Atrial Natriuretic Peptides,Atriopeptins,Auriculin,Natriuretic Peptides, Atrial,ANF (1-126),ANF (1-28),ANF (99-126),ANF Precursors,ANP (1-126),ANP (1-28),ANP Prohormone (99-126),ANP-(99-126),Atrial Natriuretic Factor (1-126),Atrial Natriuretic Factor (1-28),Atrial Natriuretic Factor (99-126),Atrial Natriuretic Factor Precursors,Atrial Natriuretic Factor Prohormone,Atrial Natriuretic Peptide (1-126),Atrial Pronatriodilatin,Atriopeptigen,Atriopeptin (1-28),Atriopeptin (99-126),Atriopeptin 126,Atriopeptin Prohormone (1-126),Cardiodilatin (99-126),Cardiodilatin Precursor,Cardionatrin I,Cardionatrin IV,Prepro-ANP,Prepro-CDD-ANF,Prepro-Cardiodilatin-Atrial Natriuretic Factor,Pro-ANF,ProANF,Proatrial Natriuretic Factor,Pronatriodilatin,alpha ANP,alpha-ANP Dimer,alpha-Atrial Natriuretic Peptide,beta-ANP,beta-Atrial Natriuretic Peptide,gamma ANP (99-126),gamma-Atrial Natriuretic Peptide,Natriuretic Peptide, Atrial,Peptide, Atrial Natriuretic,Peptides, Atrial Natriuretic,Prepro ANP,Prepro CDD ANF,Prepro Cardiodilatin Atrial Natriuretic Factor,Pro ANF,alpha ANP Dimer,alpha Atrial Natriuretic Peptide,beta ANP,beta Atrial Natriuretic Peptide,gamma Atrial Natriuretic Peptide
D002001 Adipose Tissue, Brown A thermogenic form of adipose tissue composed of BROWN ADIPOCYTES. It is found in newborns of many species including humans, and in hibernating mammals. Brown fat is richly vascularized, innervated, and densely packed with MITOCHONDRIA which can generate heat directly from the stored lipids. Brown Fat,Hibernating Gland,Brown Adipose Tissue,Fat, Brown,Tissue, Brown Adipose
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005234 Fatty Liver Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS. Liver Steatosis,Steatohepatitis,Steatosis of Liver,Visceral Steatosis,Liver Steatoses,Liver, Fatty,Steatohepatitides,Steatoses, Liver,Steatoses, Visceral,Steatosis, Liver,Steatosis, Visceral,Visceral Steatoses
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D052436 Adipose Tissue, White Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). It has less vascularization and less coloration than the BROWN FAT. White fat provides heat insulation, mechanical cushion, and source of energy. White Fat,White Adipose Tissue,Fat, White,Tissue, White Adipose

Related Publications

Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
August 2016, Best practice & research. Clinical endocrinology & metabolism,
Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
January 2017, Proceedings of the National Academy of Sciences of the United States of America,
Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
October 1988, Biochemical and biophysical research communications,
Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
June 2019, Scientific reports,
Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
January 2017, Obesity (Silver Spring, Md.),
Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
September 1988, Pharmacological research communications,
Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
December 2023, EMBO reports,
Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
August 2023, Molecular metabolism,
Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
January 2024, The Journal of physiology,
Haruka Kimura, and Tomohisa Nagoshi, and Yuhei Oi, and Akira Yoshii, and Yoshiro Tanaka, and Hirotake Takahashi, and Yusuke Kashiwagi, and Toshikazu D Tanaka, and Michihiro Yoshimura
December 1997, Journal of hypertension,
Copied contents to your clipboard!