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Previous studies have described a neurogenic-induced ventilatory tachypneic response during exercise. The present paper compares the breathing pattern of control and myopathic human subjects submitted to exercise. Peripheral neurogenic stimuli (PNS) at the same level of oxygen consumption should be enhanced in myopathic subjects as a consequence of muscular mass loss. Myopathic individuals showed hyperventilation (increased VeO2 and VeCO2) which was mostly due to higher respiratory frequency. The shorter respiratory cycle was due chiefly to Te reduction, since the Ti/TTOT ratio was greater in the myopathic individuals for a VO2 of 1 L. These results are in agreement with previous studies in anesthetized dogs and in unanesthetized humans in which a tachypneic mechanism associated to the relative work load was observed. These results also suggest that PNS may have a facilitatory effect upon the inspiratory off switch mechanism.
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
June 1987,
Journal of applied physiology (Bethesda, Md. : 1985),
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
March 1981,
Pharmacological research communications,
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
February 1989,
Respiration physiology,
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
January 1987,
European journal of applied physiology and occupational physiology,
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
January 1984,
Acta physiologica Scandinavica,
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
January 1988,
The European respiratory journal,
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
January 1991,
European journal of applied physiology and occupational physiology,
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
July 1987,
Journal of applied physiology (Bethesda, Md. : 1985),
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
January 1993,
Respiration; international review of thoracic diseases,
A C Silva, and
A K Russo, and
I C Piçarro, and
J Tarasantchi, and
B Schmidt, and
A Gabbai, and
A S Oliveira
January 1994,
European journal of applied physiology and occupational physiology,
