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Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams. 2021

Yi Zheng, and Ting-Ting Zhang, and Wen-Bo Shen
College of Sciences, Henan Agricultural University, Zhengzhou 450002, China. wenboshen@henau.edu.cn.

An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized γ-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.

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