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The mutagenicity of eight Fusarium toxins (mono-, di-, and triacetoxyscirpenol, T-2 toxin, deoxynivalenol, 3-acetyl-deoxynivalenol, zearalenone, and moniliformin) and of two positive controls (aflatoxin B1 and sterigmatocystin) to histidine-requiring strains TA 98, 100, 1535, and 1537 of Salmonella typhimurium was tested both with and without metabolic activation. Both aflatoxin B1 and sterigmatocystin, but none of the eight Fusarium toxins, were mutagenic to S. typhimurium. The lack of mutagenic activity of T-2 toxin and diacetoxyscirpenol supports the negative results that have been obtained with in vivo carcinogenicity tests. The negative mutagenicity of the four other 12,13-epoxytrichothecenes tested, and of zearalenone and moniliformin, could not be correlated with in vivo tests because published accounts of their chronic toxicity were not available.
F C Wehner, and
W F Marasas, and
P G Thiel
November 1978,
Mutation research,
F C Wehner, and
W F Marasas, and
P G Thiel
March 1978,
Cancer research,
F C Wehner, and
W F Marasas, and
P G Thiel
January 1987,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
F C Wehner, and
W F Marasas, and
P G Thiel
August 1998,
Toxicology in vitro : an international journal published in association with BIBRA,
F C Wehner, and
W F Marasas, and
P G Thiel
April 1979,
Minerva ginecologica,
F C Wehner, and
W F Marasas, and
P G Thiel
September 1978,
Mutation research,
F C Wehner, and
W F Marasas, and
P G Thiel
December 1986,
Journal of pharmacobio-dynamics,
F C Wehner, and
W F Marasas, and
P G Thiel
May 1995,
Mutagenesis,
F C Wehner, and
W F Marasas, and
P G Thiel
March 1985,
Experientia,
F C Wehner, and
W F Marasas, and
P G Thiel
November 1979,
Mutation research,
