-transparent.png){kind=logo}
The effect of a small dose of somatostatin (0.05 mg/h) on the gastric secretion of acid, pepsin and Intrinsic Factor (IF) after stepwise increases in the dose of pentagastrin was examined in six healthy volunteers. The gastric secretion of acid, pepsin and IF in response to pentagastrin was significantly reduced by a continuous infusion of somatostatin. The pattern of inhibition indicates that somatostatin is a competitive inhibitor of pentagastrin in the stimulation of gastric secretion of both acid, pepsin and IF. This finding supports the hypothesis of a direct effect of somatostatin on the exocrine secretory cells of the stomach.
Related Publications
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
May 1989,
Scandinavian journal of gastroenterology,
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
March 1974,
Annals of surgery,
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
May 1969,
The British journal of surgery,
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
January 1973,
Scandinavian journal of gastroenterology,
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
September 1984,
Digestive diseases and sciences,
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
March 1979,
Clinical endocrinology,
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
October 1978,
Acta physiologica Scandinavica,
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
January 1976,
Scandinavian journal of gastroenterology. Supplement,
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
April 1977,
The Journal of physiology,
E Schrumpf, and
M H Vatn, and
K F Hanssen, and
J Myren
July 1975,
Gut,
